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KMID : 0984720040360020068
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Infection and Chemotherapy
2004 Volume.36 No. 2 p.68 ~ p.74
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In Vitro Activities of Gatifloxacin against Bacteria isolated from Respiratory Specimens of Patients of University Hospitals in Korea
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Yong Dong-Eun
Kim Myung-Sook
Kim Sin-Young
Lee Gyeong-Won
Kim Sung-Kyu
Chong Yun-Sop
Lee Yil-Seob
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Abstract
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Background : Gatifloxacin, a new 8-methoxyquinolone, has a broad-spectrum activity with expanded potency against respiratory pathogens. In this study, we examined the in vitro activity of gatifloxacin and comparators against recently isolated bacteria from respiratory specimens of patients in Korean hospitals.
Methods : Forty-nine isolates were from respiratory specimens of patients with acute exacerbations of chronic lower respiratory infections in eight university hospitals and 108 isolates were from respiratory specimens from patients of Yonsei University Hospital. Minimum inhibitory concentrations (MICs) were determined by NCCLS agar dilution method.
Results : MICqo of gatifloxacin for Streptococcus pneumoniae was 1 pg/mL, which was 8-fold and 2-fold lower than those of ciprofloxacin and levofloxacin, respectively. All strains of Haemophilus influenzae and Moraxella (Branhamella) catarrhalis were inhibited by X0.06 pg/mL and 50.25 pg/mL of gatifloxacin, respectively, and were susceptible to all fluoroquinolones tested. MICgo of gatifloxacin for Kiebsiella pneumoniae" was 0.06 pg/mL, which was 2-fold lower than those of levofloxacin and moxifloxacin.
Conclusion : Gatifloxacin is highly active against S. pneumoniae, H. influenzae and M. (B.) catarrhalis isolated from respiratory specimens of patients of university hospitals in Korea.
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KEYWORD
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Gatifloxacin, Respiratory tract pathogens, Acute exacerbation of Chronic lower respiratory tract infection
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